HORDB

General Information

ID: hor003208
Uniprot ID: NA
Protein name: Deltorphin I
Gene name: NA
Organism: Homo sapiens
Family: Opioid neuropeptide precursor family
Source: Human
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: YAFDVVG
Length: 7
Propeptide: NA
Signal peptide: NA
Modification: T7 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: NA
Mechanism: NA
Cross BBB: YES
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003208_AF2.pdb

hor003208_ESM.pdb

Physical Information

Mass:	87706	Formula:	C37H51N7O11
Absent amino acids:	CEHIKLMNPQRSTW	Common amino acids:	V
pI:	3.75	Basic residues:	0
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	111.43	Boman Index:	495
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	97.14
Instability Index:	4790	Extinction Coefficient cystines:	1490
Absorbance 280nm:	248.33

Literature

PubMed ID: 18395423
Title: Different Kinases Desensitize the Human Delta-opioid neuropeptide precursor family Receptor (hDOP-R) in the Neuroblastoma Cell Line SK-N-BE Upon Peptidic and Alkaloid Agonists