General Information

  • ID:  hor003208
  • Uniprot ID:  NA
  • Protein name:  Deltorphin I
  • Gene name:  NA
  • Organism:  Homo sapiens
  • Family:  Opioid neuropeptide precursor family
  • Source:  Human
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  YAFDVVG
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003208_AF2.pdbhor003208_ESM.pdb

Physical Information

Mass: 87706 Formula: C37H51N7O11
Absent amino acids: CEHIKLMNPQRSTW Common amino acids: V
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 111.43 Boman Index: 495
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 97.14
Instability Index: 4790 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  18395423
  • Title:  Different Kinases Desensitize the Human Delta-opioid neuropeptide precursor family Receptor (hDOP-R) in the Neuroblastoma Cell Line SK-N-BE Upon Peptidic and Alkaloid Agonists